Article
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
Biochemistry - 4 Feb 2014
Wagner Steven L, Zhang Can, Cheng Soan, Nguyen Phuong, Zhang Xulun, Rynearson Kevin D, Wang Rong, Li Yueming, Sisodia Sangram S, Mobley William C, Tanzi Rudolph E
Abstract excerpt
Alzheimer's disease (AD) is characterized pathologically by an abundance of extracellular neuritic plaques composed primarily of the 42-amino acid amyloid β peptide variant (Aβ42). In the majority of familial AD (FAD) cases, e.g., those harboring mutations in presenilin 1 (PS1), there is a relative increase in the levels of Aβ42 compared to the levels of Aβ40. We previously reported the characterization of a...
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