Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.

Gene expression - 1 Jan 2002

Xiang Zhongmin, Ho Lap, Yemul Shrishailam, Zhao Zhong, Qing Wein, Pompl Patrick, Kelley Kevin, Dang Anju, Qing Weiping, Teplow David, Pasinetti Giulio Maria

Abstract excerpt

Several epidemiologic studies have reported that cyclooxygenase (COX) inhibitors prevent/delay the onset of Alzheimer's disease (AD). Recent experimental studies suggest that these compounds can also diminish amyloid-beta (Abeta) neuropathology in rodent models of AD. To explore the relationship...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Cyclooxygenase 2
Share to Dinoprostone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Image Processing, Computer-Assisted

Share to Inflammation

Share to Isoenzymes

Share to Mass Spectrometry

Share to Prostaglandin-Endoperoxide Synthases

Source

Open in PubMed Open full text

Identifiers

PMID: 12450219
DOI: 10.3727/000000002783992352
PMCID: PMC5977525

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12450219-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.PMID 12450219Read ↗

Genetic Deletion of cyclooxygenase-1 ameliorates neuroinflammation and cognitive impairment in 5×FAD miceSemantic proximity Read ↗

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.Semantic proximity Read ↗

Prostacyclin Promotes Degenerative Pathology in a Model of Alzheimer’s diseaseSemantic proximity Read ↗

Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice.Semantic proximity Read ↗

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.Semantic proximity Read ↗

Prostaglandin D2 pathway in a transgenic rat model of Alzheimer’s disease: therapeutic potential of timapiprant a DP2 antagonistSemantic proximity Read ↗

Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Sustained Interleukin-1β overexpression exacerbates Tau pathology in a murine tauopathy model via cyclooxygenase-1Semantic proximity Read ↗

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.Semantic proximity Read ↗

Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.