Article
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
The Journal of biological chemistry - 11 Jan 2008
Page Richard M, Baumann Karlheinz, Tomioka Masanori, Pérez-Revuelta Blanca I, Fukumori Akio, Jacobsen Helmut, Flohr Alexander, Luebbers Thomas, Ozmen Laurence, Steiner Harald, Haass Christian
Abstract excerpt
Alzheimer disease amyloid beta-peptide (Abeta) is generated via proteolytic processing of the beta-amyloid precursor protein by beta- and gamma-secretase. Gamma-secretase can be blocked by selective inhibitors but can also be modulated by a subset of non-steroidal anti-inflammatory drugs, includi...
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