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Article

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

British journal of pharmacology - 1 Mar 2009

Imbimbo B P, Hutter-Paier B, Villetti G, Facchinetti F, Cenacchi V, Volta R, Lanzillotta A, Pizzi M, Windisch M

Abstract excerpt

BACKGROUND AND PURPOSE: We evaluated the effects of 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a new gamma-secretase modulator, on brain beta-amyloid pathology and spatial memory in transgenic mice expressing the Swedish and London mutations of human amyloid precursor protein (hAPP). EXPERIMENTAL APPROACH: Sixty 6-month-old hAPP mice were treated for 6 months with...

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Identifiers

PMID: 19239474
DOI: 10.1111/j.1476-5381.2008.00097.x
PMCID: PMC2697723

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