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Article

Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line.

Journal of molecular neuroscience : MN - 1 Mar 2011

Czvitkovich Stefan, Duller Stephan, Mathiesen Else, Lorenzoni Klaus, Imbimbo Bruno P, Hutter-Paier Birgit, Windisch Manfred, Wronski Robert

Abstract excerpt

Sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretases and the formation of Aβ peptides are pivotal for Alzheimer's disease. Therefore, a large number of drugs has been developed targeting APP metabolism. However, many pharmacological compounds have been identified in vitro in immortalized APP overexpressing cell lines rather than in primary neurons. Here, we compared the effect of already...

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Source

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Identifiers

PMID: 20603724
DOI: 10.1007/s12031-010-9416-z
PMCID: PMC3041911

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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