Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.

doi:10.1038/ncomms12504

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.

Nature communications - 11 Aug 2016

Daniels Michael J D, Rivers-Auty Jack, Schilling Tom, Spencer Nicholas G, Watremez William, Fasolino Victoria, Booth Sophie J, White Claire S, Baldwin Alex G, Freeman Sally, Wong Raymond, Latta Clare, Yu Shi, Jackson Joshua, Fischer Nicolas, Koziel Violette, Pillot Thierry, Bagnall James, Allan Stuart M, Paszek Pawel, Galea James, Harte Michael K, Eder Claudia, Lawrence Catherine B, Brough David

Abstract excerpt

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many inflammatory diseases. Here we show that several clinically approved and widely used NSAIDs of the fenamate class are effective and selective inhibitors of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Cells

Share to Chloride Channels

Share to Inflammasomes

Share to Interleukin-1beta

Share to Memory Disorders

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Pattern Recognition, Visual

Source

Open in PubMed Open full text

Identifiers

PMID: 27509875
DOI: 10.1038/ncomms12504
PMCID: PMC4987536

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.PMID 27509875Read ↗

N,N-Dimethylacetamide Targets Neuroinflammation in Alzheimer’s Disease in In-vitro and Ex-vivo ModelsSemantic proximity Read ↗

Fluvoxamine maleate ameliorates Alzheimer disease pathology by mitigating amyloid-beta load and neuroinflammation in 5XFAD miceSemantic proximity Read ↗

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.Semantic proximity Read ↗

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.Semantic proximity Read ↗

Soothing the Inflamed Brain: Effect of Non-Steroidal Anti-Inflammatory Drugs on Alzheimers Disease PathologySemantic proximity Read ↗

A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic MiceSemantic proximity Read ↗

Subacute Inhalation of Ultrafine Particulate Matter Triggers Inflammation Without Altering Amyloid Beta Load in 5xFAD miceSemantic proximity Read ↗

4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice.Semantic proximity Read ↗

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Age-linked suppression of lipoxin A4 mediates cognitive deficits in mice and humansSemantic proximity Read ↗

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model.Semantic proximity Read ↗

Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG regionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.