Article

Prostaglandin D2 pathway in a transgenic rat model of Alzheimer’s disease: therapeutic potential of timapiprant a DP2 antagonist

2022-04-01

Abstract excerpt

The cyclooxygenase pathway, a key mediator of inflammation, is implicated in Alzheimer’s disease (AD). A deeper investigation is required into the contributions of this pathway to the neuropathology of AD. Cyclooxygenases produce prostaglandins, which have multiple receptors and functions including inflammation, nociception, sleep, cardiovascular maintenance and reproduction. In the brain, prostaglandin D2 (PGD2)...

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Literature Corpus work: e87afad7-d2e0-5275-9c9c-1d7abab7b10f
DOI: 10.1101/2022.03.30.486444

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