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Article

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.

The Journal of biological chemistry - 20 Jun 2008

Czirr Eva, Cottrell Barbara A, Leuchtenberger Stefanie, Kukar Thomas, Ladd Thomas B, Esselmann Hermann, Paul Sabine, Schubenel Robert, Torpey Justin W, Pietrzik Claus U, Golde Todd E, Wiltfang Jens, Baumann Karlheinz, Koo Edward H, Weggen Sascha

Abstract excerpt

Proteolytic processing of the amyloid precursor protein by beta- and gamma-secretase generates the amyloid-beta (Abeta) peptides, which are principal drug targets in Alzheimer disease therapeutics. gamma-Secretase has imprecise cleavage specificity and generates the most abundant Abeta40 and Abeta42 species together with longer and shorter peptides such as Abeta38. Several mechanisms could explain the production...

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Identifiers

PMID: 18426795
DOI: 10.1074/jbc.M802912200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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