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Article

Selective inhibition of Abeta42 production by NSAID R-enantiomers.

Journal of neurochemistry - 1 Nov 2002

Morihara T, Chu T, Ubeda O, Beech W, Cole G M

Abstract excerpt

Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with reduced risk for Alzheimer's disease (AD) and selected NSAIDs racemates suppress beta-amyloid (Abeta) accumulation in vivo and Abeta42 production in vitro. Clinical use of NSAIDs for preventing or treating AD has been hampered by dose-limiting toxicity believed to be due to cyclooxygenase (COX)-inhibition that is reportedly not essential for...

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Identifiers

PMID: 12421374
DOI: 10.1046/j.1471-4159.2002.01195.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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