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Article

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Nature genetics - 1 Mar 2007

Yamanouchi Jun, Rainbow Dan, Serra Pau, Howlett Sarah, Hunter Kara, Garner Valerie E S, Gonzalez-Munoz Andrea, Clark Jan, Veijola Riitta, Cubbon Rose, Chen Show-Ling, Rosa Raymond, Cumiskey Anne Marie, Serreze David V, Gregory Simon, Rogers Jane, Lyons Paul A, Healy Barry, Smink Luc J, Todd John A, Peterson Laurence B, Wicker Linda S, Santamaria Pere

Abstract excerpt

Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with differential expression of the key immunoregulatory cytokine interleukin-2 (IL-2). In order to test directly that an approximately twofold reduction in IL-2 underpins the Idd3-linked...

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Source

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Identifiers

PMID: 17277778
DOI: 10.1038/ng1958
PMCID: PMC2886969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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