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Article

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.

Immunity - 20 Feb 2009

Yu Aixin, Zhu Linjian, Altman Norman H, Malek Thomas R

Abstract excerpt

Interleukin-2 receptor (IL-2R) signaling is essential for T regulatory (Treg) cell development and homeostasis. Here, we show that expression of IL-2Rbeta chains that lack tyrosine residues important for the association of the adaptor Shc and the transcription factor STAT5 in IL-2Rbeta-deficient mice resulted in production of a normal proportion of natural Treg cells that suppressed severe autoimmunity related...

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Source

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Identifiers

PMID: 19185518
DOI: 10.1016/j.immuni.2008.11.014
PMCID: PMC2962446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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