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Article

The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice.

Journal of clinical immunology - 1 Nov 2008

Dendrou Calliope A, Wicker Linda S

Abstract excerpt

Although the interleukin-2 (IL-2)/IL-2R signaling pathway has been the focus of numerous studies, certain aspects of its molecular regulation are not well characterized, especially in non-T cells, and a more complete understanding of the pathway is necessary to discern the functional basis of the genetic association between the IL-2-IL-21 and IL-2RA/CD25 gene regions and T1D in humans. Genetic variation in these...

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Source

Identifiers

PMID: 18780166
DOI: 10.1007/s10875-008-9237-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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