Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.

doi:10.4049/jimmunol.178.7.4062

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2007

Bayer Allison L, Yu Aixin, Malek Thomas R

Abstract excerpt

IL-2 contributes to the production, function, and homeostasis of CD4+CD25+ T(reg) cells. However, it remains uncertain whether IL-2 is essential for the development of T(reg) cells in the thymus, their homeostasis in the periphery, or both. The present study was undertaken to investigate the contribution of IL-2 during thymic T(reg) cell development and its maintenance in peripheral immune tissue. Relying on...

Topics

Animals
CD4 Antigens
Forkhead Transcription Factors
Homeostasis
Immune Tolerance
Interleukin-2
Interleukin-2 Receptor alpha Subunit
Interleukin-2 Receptor beta Subunit
Mice
Mice, Inbred Strains
Phenotype
Receptors, Interleukin-2
Signal Transduction
T-Lymphocytes, Regulatory
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 17371960
DOI: 10.4049/jimmunol.178.7.4062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics