Article

The transcriptional cofactor IRF2BP2 plays a key role in T cell homeostasis and Treg cell expansion

2021-07-30

Abstract excerpt

The levels of the co-transcriptional regulator IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein-2) decrease with T cell activation and, when ectopically expressed, it reduces T cell proliferation. To further characterize the function of IRF2BP2 in T cell responses in vivo, we generated a conditional transgenic knock-in mouse that overexpresses IRF2BP2 in T lymphocytes. Overexpression of IRF2BP2 leads to a r...

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Literature Corpus work: 3d83c11f-b29e-53a6-91af-b57f8c77851f
DOI: 10.1101/2021.07.29.454283

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