Article

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

2023-06-18

Abstract excerpt

Genetic variants associated with human autoimmune diseases commonly map to non-coding control regions, particularly enhancers that function selectively in immune cells and fine-tune gene expression within a relatively narrow range of values. How such modest, cell-type-selective changes can meaningfully shape organismal disease risk remains unclear. To explore this issue, we experimentally manipulated species-conse...

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Literature Corpus work: addf85ce-e6df-5480-aafb-3008abb71962
DOI: 10.1101/2023.06.17.545426

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