Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming.

doi:10.1038/s41467-025-67813-2

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Article

Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming.

Nature communications - 3 Jan 2026

Rusznak Mark, Toki Shinji, Hao Yajing, Todd Marc J C, Malone Liddy, Goodhead Julia F, DuPuy Catherine, Zhou Weisong, Babin Dominique, Warren Christian M, Abney Masako, Stier Matthew T, Thomas Christopher M, Li Jing, Jacobse Justin, Pahnke Andrew P, Petrovic Mark I, Cephus Jacqueline-Yvonne, Kuehnle Shelby N, Calcutt M Wade, Norlander Allison E, Yan Fang, Goettel Jeremy A, Miller Darla R, Lynch Rachel M, Cook Daniel P, Newcomb Dawn C, Zou Fei, Peebles R Stokes

Abstract excerpt

Pulmonary group 2 innate lymphoid cells (ILC2s) are key drivers of Type 2 inflammation in diseases like asthma, yet the molecular mechanisms regulating their function are incompletely understood. Using the genetically diverse Collaborative Cross (CC) mouse panel, we mapped a quantitative trait locus (QTL) that governs ILC2 prevalence in the lung after aeroallergen exposure. This QTL induces a large population of...

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Identifiers

PMID: 41484153
DOI: 10.1038/s41467-025-67813-2
PMCID: PMC12847941

Genes

FFAR3
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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