Article
Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species.
Biochemical Society transactions - 1 Jun 2008
Rainbow Dan B, Esposito Laura, Howlett Sarah K, Hunter Kara M, Todd John A, Peterson Laurence B, Wicker Linda S
Abstract excerpt
Variants within the IL-2 (interleukin 2) and CD25 genes are associated with T1DM (Type 1 diabetes mellitus) in mice and humans respectively. Both gene products are essential for optimal immune tolerance and a partial failure to tolerize is linked to the autoimmune responses to insulin and other beta-cell proteins that precede T1DM onset. Gene variants that contribute to common disease susceptibility often alter...
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