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Article

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

17 May 2022

Abstract excerpt

Interleukin 2 (IL-2) is a key homeostatic cytokine, with therapeutic applications in both immunogenic and tolerogenic immune modulation. Clinical use has been hampered by pleiotropic functionality and widespread receptor expression, with unexpected adverse events. Here, we developed a novel mouse strain to divert IL-2 production, allowing identification of contextual outcomes. Network analysis identified priority...

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PMID: 35699942
DOI: 10.1084/jem.20212391

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