Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel duplication type of CYP2A6 gene in African-American population.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2007

Fukami Tatsuki, Nakajima Miki, Yamanaka Hiroyuki, Fukushima Yasunari, McLeod Howard L, Yokoi Tsuyoshi

Abstract excerpt

Human CYP2A6 is responsible for the metabolism of nicotine and its genetic polymorphisms affect smoking behavior and risk of lung cancer. In the present study, we identified a novel type of CYP2A6 gene duplication that is created through an unequal crossover event with the CYP2A7 gene at 5.2 to 5.6 kilobases downstream from the stop codon. The novel duplication type of CYP2A6 was found in African Americans (n =...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cotinine
Share to Crossing Over, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2A6

Share to Cytochrome P450 Family 2

Share to Gene Duplication

Share to Mixed Function Oxygenases

Share to Nicotine

Share to Nicotinic Agonists

Source

Identifiers

PMID: 17267622
DOI: 10.1124/dmd.106.013557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel duplication type of CYP2A6 gene in African-American population.PMID 17267622Read ↗

Novel human CYP2A6 alleles confound gene deletion analysis.Semantic proximity Read ↗

Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking.Semantic proximity Read ↗

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.Semantic proximity Read ↗

CYP2A6 genetic variation and potential consequences.Semantic proximity Read ↗

A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity.Semantic proximity Read ↗

Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.Semantic proximity Read ↗

New CYP2A6 gene deletion and conversion variants in a population of Black African descent.Semantic proximity Read ↗

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.Semantic proximity Read ↗

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.Semantic proximity Read ↗

CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.Semantic proximity Read ↗

Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism.Semantic proximity Read ↗

The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.