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Article

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

Human mutation - 1 May 2008

Mwenifumbo Jill C, Al Koudsi Nael, Ho Man Ki, Zhou Qian, Hoffmann Ewa B, Sellers Edward M, Tyndale Rachel F

Abstract excerpt

Cytochrome P450 2A6 (CYP2A6) is a human enzyme best known for metabolizing tobacco-related compounds, such as nicotine, cotinine (COT), and nitrosamine procarcinogens. CYP2A6 genetic variants have been associated with smoking status, cigarette consumption, and tobacco-related cancers. Our objective was to functionally characterize four nonsynonymous CYP2A6 sequence variants with respect to their haplotype, allele...

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Identifiers

PMID: 18360915
DOI: 10.1002/humu.20698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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