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Article

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.

Clinical pharmacology and therapeutics - 1 Feb 2007

Gaedigk A, Ndjountché L, Divakaran K, Dianne Bradford L, Zineh I, Oberlander T F, Brousseau D C, McCarver D G, Johnson J A, Alander S W, Wayne Riggs K, Steven Leeder J

Abstract excerpt

Duplications and multiplications of active CYP2D6 genes can cause ultrarapid drug metabolism and lead to therapeutic failure. Multiple functional and non-functional duplication alleles have been further characterized. Duplications were detected by long-range polymerase chain reaction (PCR), PCR-restriction fragment length polymorphism, and sequence analysis. A PCR fragment encompassing the entire duplicated gene...

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PMID: 17259947
DOI: 10.1038/sj.clpt.6100033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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