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Article

New CYP2A6 gene deletion and conversion variants in a population of Black African descent.

Pharmacogenomics - 1 Feb 2010

Mwenifumbo Jill C, Zhou Qian, Benowitz Neal L, Sellers Edward M, Tyndale Rachel F

Abstract excerpt

AIMS: Cytochrome P450 2A6 (CYP2A6) is a human enzyme best known for metabolizing nicotine and nitrosamine precarcinogens. Our aim was to discover and characterize new CYP2A6 alleles in a population of Black African descent. MATERIALS & METHODS: We used cloning, sequencing and genotyping of genomic DNA to discover new variants, and in vivo nicotine pharmacokinetic phenotyping to characterize the functional effect...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20136358
DOI: 10.2217/pgs.09.144
PMCID: PMC2922202

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Source receipt: pubmed, retrieved 7 Sept 2026.

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