Article
CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.
The pharmacogenomics journal - 1 Jan 2000
Fukami T, Nakajima M, Sakai H, McLeod H L, Yokoi T
Abstract excerpt
Human cytochrome P450 (CYP) 2A6 metabolizes nicotine to cotinine. Genetic polymorphisms of CYP2A6 contribute to the interindividual variability of nicotine metabolism. We encountered some subjects possessing two copies of the CYP2A6 gene, although they were genotyped as heterozygotes of the CYP2A...
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