Article
Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.
Oncology - 1 Jan 2001
Agúndez J A, Gallardo L, Ledesma M C, Lozano L, Rodriguez-Lescure A, Pontes J C, Iglesias-Moreno M C, Poch J, Ladero J M, Benítez J
Abstract excerpt
The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of developing lung cancer, with individuals with high activity being at increased risk. The occurrence of functionally active duplications of the CYP2D6 gene is a phenomenon...
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