Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel human CYP2A6 alleles confound gene deletion analysis.

FEBS letters - 2 Jul 2004

Nakajima Miki, Yoshida Ryoko, Fukami Tatsuki, McLeod Howard L, Yokoi Tsuyoshi

Abstract excerpt

Cytochrome P450 (CYP) 2A6 metabolizes a number of drugs and a variety of procarcinogens. CYP2A6 also catalyzes nicotine C-oxidation leading to cotinine formation, a major metabolic pathway of nicotine in humans. There are genetic polymorphisms in the human CYP2A6 gene and a relationship between the CYP2A6 genotype and smoking habits as well as the incidence of lung cancer has been indicated. CYP2A6*4 alleles are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2A6
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Techniques

Share to Introns

Share to Mixed Function Oxygenases

Share to Oligodeoxyribonucleotides

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 15225612
DOI: 10.1016/j.febslet.2004.05.053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel human CYP2A6 alleles confound gene deletion analysis.PMID 15225612Read ↗

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.Semantic proximity Read ↗

Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking.Semantic proximity Read ↗

Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence.Semantic proximity Read ↗

Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.Semantic proximity Read ↗

A novel duplication type of CYP2A6 gene in African-American population.Semantic proximity Read ↗

The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP.Semantic proximity Read ↗

CYP2A6 genetic variation and potential consequences.Semantic proximity Read ↗

New CYP2A6 gene deletion and conversion variants in a population of Black African descent.Semantic proximity Read ↗

Association between nicotine metabolism and CYP2A6*1 and CYP2A6*4 genotypes in an Iranian population.Semantic proximity Read ↗

Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism.Semantic proximity Read ↗

Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.Semantic proximity Read ↗

Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.