Article
Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking.
Molecular pharmacology - 1 Oct 2000
Rao Y, Hoffmann E, Zia M, Bodin L, Zeman M, Sellers E M, Tyndale R F
Abstract excerpt
In humans, 80% of nicotine is metabolized to the inactive metabolite cotinine by the enzyme CYP2A6, which can also activate tobacco smoke procarcinogens (e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone). Previously, we demonstrated that individuals who are nicotine-dependent and have defective CYP2A6 alleles (*2, *3) smoked fewer cigarettes; however, we recognize that the genotyping method used for the...
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