CYP2A6 genetic variation and potential consequences.

doi:10.1016/s0169-409x(02)00065-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

CYP2A6 genetic variation and potential consequences.

Advanced drug delivery reviews - 18 Nov 2002

Xu Chun, Goodz Shari, Sellers Edward M, Tyndale Rachel F

Abstract excerpt

Human cytochrome P450 2A6 (CYP2A6) has been shown to have large interindividual and interethnic variability in levels of expression and activity. This is thought to be largely due to genetic polymorphisms. In recent years, 13 genetic variants (CYP2A6*1-*11 and the gene duplication, *1 x 2) of CYP2A6 have been identified and a number of these have been shown to result in altered CYP2A6 enzyme activity. For...

Topics

Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2A6
Enzyme Inhibitors
Gene Frequency
Genetic Variation
Humans
Mixed Function Oxygenases
Neoplasms
Nicotine
Smoking

Source

Open in PubMed

Identifiers

PMID: 12406643
DOI: 10.1016/s0169-409x(02)00065-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics