Article
A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity.
Biochemical pharmacology - 1 Sept 2005
Fukami Tatsuki, Nakajima Miki, Higashi Eriko, Yamanaka Hiroyuki, McLeod Howard L, Yokoi Tsuyoshi
Abstract excerpt
Human CYP2A6 is a cytochrome P450 (CYP) isoform responsible for the metabolism of nicotine, coumarin, tegafur, and valproic acid, and metabolic activation of nitrosamines. Genetic polymorphisms of the CYP2A6 gene are a major causal factor of the large interindividual differences in nicotine metabolism. In the present study, we identified a novel allele, termed CYP2A6*20, in an African-American population. The...
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