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Article

Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog.

Mechanisms of development - 1 Jan 2000

Babbs Christian, Furniss Dominic, Morriss-Kay Gillian M, Wilkie Andrew O M

Abstract excerpt

The mouse mutant Doublefoot (Dbf) shows preaxial polydactyly with 6-9 triphalangeal digits in all four limbs and additional abnormalities including a broadened skull, hydrocephalus, and a thickened, kinked tail. The autopod undergoes a characteristic expansion between late embryonic day (E) 10.5 and E11.5, following the onset of ectopic Indian hedgehog (Ihh) expression in the entire distal mesenchyme, except for...

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Identifiers

PMID: 18272352
DOI: 10.1016/j.mod.2008.01.001
PMCID: PMC2428104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog.PMID 18272352Read ↗

Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.Semantic proximity Read ↗

Some distal limb structures develop in mice lacking Sonic hedgehog signaling.Semantic proximity Read ↗

Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud.Semantic proximity Read ↗

An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression.Semantic proximity Read ↗

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.Semantic proximity Read ↗

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.Semantic proximity Read ↗

Morphogenesis of Doublefoot (Dbf), a mouse mutant with polydactyly and craniofacial defects.Semantic proximity Read ↗

A duplicated zone of polarizing activity in polydactylous mouse mutants.Semantic proximity Read ↗

Long bone development requires a threshold of Hox function.Semantic proximity Read ↗

A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype.Semantic proximity Read ↗

Shh, HoxD, Bmp-2, and Fgf-4 gene expression during development of the polydactylous talpid2, diplopodia1, and diplopodia4 mutant chick limb buds.Semantic proximity Read ↗

Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.Semantic proximity Read ↗

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