Article
Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud.
Development (Cambridge, England) - 1 Dec 2003
Krebs Ottheinz, Schreiner Claire M, Scott William J, Bell Sheila M, Robbins David J, Goetz John A, Alt Heidi, Hawes Norm, Wolf Eckhard, Favor Jack
Abstract excerpt
A unique limb phenotype is described in a radiation-induced mutant mouse resulting from an inversion of a proximal segment of chromosome 5. The limb phenotype in the homozygous mutant presents with two anterior skeletal elements in the zeugopod but no posterior bone, hence the name replicated anterior zeugopod, raz. The zeugopod phenotype is accompanied by symmetrical central polydactyly of hand and foot. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
