Article
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.
Development (Cambridge, England) - 1 Apr 2000
Park H L, Bai C, Platt K A, Matise M P, Beeghly A, Hui C C, Nakashima M, Joyner A L
Abstract excerpt
The secreted factor Sonic hedgehog (SHH) is both required for and sufficient to induce multiple developmental processes, including ventralization of the CNS, branching morphogenesis of the lungs and anteroposterior patterning of the limbs. Based on analogy to the Drosophila Hh pathway, the multiple GLI transcription factors in vertebrates are likely to both transduce SHH signaling and repress Shh transcription....
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