Article
The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.
Developmental biology - 15 May 2003
Meyer Néva P, Roelink Henk
Abstract excerpt
A concentration gradient of Shh is thought to pattern the ventral neural tube, and these ventral cell types are absent in shh-/- mice. Based on in vitro and genetic studies, the zinc finger-containing transcription factors Gli 1, 2, and 3 are mediators of the Shh intracellular response. The floorplate and adjacent cell types are absent in gli1-/-;gli2-/- mice, but part of the Shh-/- phenotype in the neural tube...
Topics
- Animals
- Body Patterning
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins
- Chick Embryo
- DNA-Binding Proteins
- Embryonic Induction
- Eye Proteins
- Gene Expression Regulation, Developmental
- Hedgehog Proteins
- Homeobox Protein Nkx-2.2
- Homeodomain Proteins
- Kruppel-Like Transcription Factors