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Article

Hoxd and Gli3 interactions modulate digit number in the amniote limb.

Developmental biology - 15 Oct 2007

Sheth Rushikesh, Bastida M Félix, Ros Marian

Abstract excerpt

During limb development, Sonic hedgehog (SHH) and HOX proteins are considered among the most important factors regulating digit number and identity. SHH signaling prevents the processing of GLI3 into a short form that functions as a strong transcriptional repressor. Gli3 mutant limbs are characterized by a severe polydactyly and associated ectopic anterior expression of 5'Hoxd genes. To genetically determine the...

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Source

Identifiers

PMID: 17714700
DOI: 10.1016/j.ydbio.2007.07.023

Genes

SHH
GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hoxd and Gli3 interactions modulate digit number in the amniote limb.PMID 17714700Read ↗

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