Article
Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients.
Immunogenetics - 1 Mar 2007
Rubio Justin P, Bahlo Melanie, Stankovich Jim, Burfoot Rachel K, Johnson Laura J, Huxtable Stewart, Butzkueven Helmut, Lin Ling, Taylor Bruce V, Speed Terence P, Kilpatrick Trevor J, Mignot Emmanuel, Foote Simon J
Abstract excerpt
Human leucocyte antigen (HLA)-DRB1*15 is associated with predisposition to multiple sclerosis (MS), although conjecture surrounds the possible involvement of an alternate risk locus in the class I region of the HLA complex. We have shown previously that an alternate MS risk allele(s) may be encompassed by the telomerically extended DRB1*15 haplotype, and here, we have attempted to map the putative variant....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.