Article
Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis.
American journal of human genetics - 1 May 2002
Rubio Justin P, Bahlo Melanie, Butzkueven Helmut, van Der Mei Ingrid A F, Sale Michèle M, Dickinson Joanne L, Groom Patricia, Johnson Laura J, Simmons Rex D, Tait Brian, Varney Mike, Taylor Bruce, Dwyer Terence, Williamson Robert, Gough Nicholas M, Kilpatrick Trevor J, Speed Terence P, Foote Simon J
Abstract excerpt
Association of multiple sclerosis (MS) with the human leukocyte antigen (HLA) class II haplotype DRB1*1501-DQB1*0602 is the most consistently replicated finding of genetic studies of the disease. However, the high level of linkage disequilibrium (LD) in the HLA region has hindered the identification of other loci that single-marker tests for association are unlikely to resolve. In order to address this issue, we...
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