Article
High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility.
Frontiers in immunology - 1 Jan 2021
Osoegawa Kazutoyo, Creary Lisa E, Montero-Martín Gonzalo, Mallempati Kalyan C, Gangavarapu Sridevi, Caillier Stacy J, Santaniello Adam, Isobe Noriko, Hollenbach Jill A, Hauser Stephen L, Oksenberg Jorge R, Fernández-Viňa Marcelo A
Abstract excerpt
Multiple sclerosis (MS) susceptibility shows strong genetic associations with HLA alleles and haplotypes. We genotyped 11 HLA genes in 477 non-Hispanic European MS patients and their 954 unaffected parents using a validated next-generation sequencing (NGS) methodology. HLA haplotypes were assigned unequivocally by tracing HLA allele transmissions. We explored HLA haplotype/allele associations with MS using the...
Topics
- Adolescent
- Adult
- Alleles
- Case-Control Studies
- Child
- Female
- Genetic Predisposition to Disease
- Genotyping Techniques
- HLA-DP Antigens
- Haplotypes