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Article

Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase.

Journal of virology - 1 Apr 2007

Marcotte Laura L, Wass Amanda B, Gohara David W, Pathak Harsh B, Arnold Jamie J, Filman David J, Cameron Craig E, Hogle James M

Abstract excerpt

Poliovirus 3CD is a multifunctional protein that serves as a precursor to the protease 3C(pro) and the viral polymerase 3D(pol) and also plays a role in the control of viral replication. Although 3CD is a fully functional protease, it lacks polymerase activity. We have solved the crystal structures of 3CD at a 3.4-A resolution and the G64S fidelity mutant of 3D(pol) at a 3.0-A resolution. In the 3CD structure,...

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Identifiers

PMID: 17251299
DOI: 10.1128/JVI.02306-06
PMCID: PMC1866080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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