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Crystal Structure of Coxsackievirus B3 3D <sup>pol</sup> Highlights the Functional Importance of Residue 5 in Picornavirus Polymerases

17 Jul 2008

Abstract excerpt

The crystal structure of the coxsackievirus B3 polymerase has been solved at 2.25-A resolution and is shown to be highly homologous to polymerases from poliovirus, rhinovirus, and foot-and-mouth disease viruses. Together, these structures highlight several conserved structural elements in picornaviral polymerases, including a proteolytic activation-dependent N-terminal structure that is essential for full...

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PMID: 18632862
DOI: 10.1128/jvi.00647-08

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