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Article

Complete protein linkage map of poliovirus P3 proteins: interaction of polymerase 3Dpol with VPg and with genetic variants of 3AB.

Journal of virology - 1 Aug 1998

Xiang W, Cuconati A, Hope D, Kirkegaard K, Wimmer E

Abstract excerpt

Poliovirus has evolved to maximize its genomic information by producing multifunctional viral proteins. The P3 nonstructural proteins harbor various activities when paired with different binding partners. These viral polypeptides regulate host cell macromolecular synthesis and function as proteinases, as RNA binding proteins, or as RNA-dependent RNA polymerase. A cleavage product of the P3 region is the...

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Identifiers

PMID: 9658121
DOI: 10.1128/JVI.72.8.6732-6741.1998
PMCID: PMC109881

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