Article
Molecular dissection of the multifunctional poliovirus RNA-binding protein 3AB.
RNA (New York, N.Y.) - 1 Nov 1995
Xiang W, Cuconati A, Paul A V, Cao X, Wimmer E
Abstract excerpt
Genome replication of poliovirus, as yet unsolved, involves numerous viral polypeptides that arise from proteolysis of the viral polyprotein. One of these proteins is 3AB, an RNA-binding protein with multiple functions, that serves also as the precursor for the genome-linked protein VPg (= 3B). Eight clustered charged amino acid-to-alanine mutants in the 3AB coding region of poliovirus were constructed and...
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