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Structure of the aminoterminal domain of the birnaviral multifunctional VP3 protein and its unexplored critical role

20 Nov 2024

Abstract excerpt

To overcome their limited genetic capacity, numerous viruses encode multifunctional proteins. The birnavirus VP3 protein plays key roles during infection, including scaffolding of the viral capsid during morphogenesis, recruitment, and regulation of the viral RNA polymerase, shielding of the double-stranded RNA genome and targeting of host endosomes for genome replication, and immune evasion. The dimeric form of...

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PMID: 39677362
DOI: 10.1093/pnasnexus/pgae521

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