Article
Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis.
Journal of virology - 1 Jan 2007
Sweeney Trevor R, Roqué-Rosell Núria, Birtley James R, Leatherbarrow Robin J, Curry Stephen
Abstract excerpt
The 3C protease (3C(pro)) from foot-and-mouth disease virus (FMDV), the causative agent of a widespread and economically devastating disease of domestic livestock, is a potential target for antiviral drug design. We have determined the structure of a new crystal form of FMDV 3C(pro), a chymotryps...
Topics
- 3C Viral Proteases
- Binding Sites
- Crystallography, X-Ray
- Cysteine Endopeptidases
- Foot-and-Mouth Disease Virus
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- Protein Structure, Tertiary
- Substrate Specificity
- Viral Proteins