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Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in Picornaviruses

21 Jun 2022

Abstract excerpt

Picornaviridae is a group of RNA viruses that harm both humans and livestock. 3C pro is an essential enzyme for picornavirus maturation, which makes it a promising target for antiviral drug development and a critical component for virus-like particle (VLP) production. However, the current challenge in the development of antiviral drugs and VLP vaccines includes the limited knowledge of how subsite structure...

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PMID: 35727031
DOI: 10.1128/jvi.00736-22

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