Article
Picornavirus RNA-dependent RNA polymerase.
The international journal of biochemistry & cell biology - 1 Mar 2009
Kok Chee Choy, McMinn Peter C
Abstract excerpt
Replication of the picornavirus genome is catalysed by a viral encoded RNA-dependent RNA polymerase, termed 3D polymerase. Together with other viral and host proteins, this enzyme performs its functions in the cytoplasm of host cells. The crystal structure of 3D polymerase from a number of picornaviruses has been determined. This review discusses the structure and function of the poliovirus 3D polymerase. The...
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