Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

doi:10.1128/jvi.01788-07

Article

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

17 Oct 2007

Abstract excerpt

Several flaviviruses are important human pathogens, including dengue virus, a disease against which neither a vaccine nor specific antiviral therapies currently exist. During infection, the flavivirus RNA genome is translated into a polyprotein, which is cleaved into several components. Nonstructural protein 3 (NS3) carries out enzymatic reactions essential for viral replication, including proteolysis of the...

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