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Article

The impact of apolipoprotein E on dementia in persons with Down's syndrome.

Neurobiology of aging - 1 Jun 2008

Coppus A M W, Evenhuis H M, Verberne G-J, Visser F E, Arias-Vasquez A, Sayed-Tabatabaei F A, Vergeer-Drop J, Eikelenboom P, van Gool W A, van Duijn C M

Abstract excerpt

Apolipoprotein E (APOE) is consistently associated with dementia in the general population. Findings on the role of this gene in persons with Down's syndrome (DS) are inconclusive. We studied the effects of APOE on mortality and dementia in a longitudinal prospective study of a large population-based sample of persons with DS (n=425), demented and non-demented. There was evidence that APOE epsilon4 is correlated...

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Source

Identifiers

PMID: 17250929
DOI: 10.1016/j.neurobiolaging.2006.12.013

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of apolipoprotein E on dementia in persons with Down's syndrome.PMID 17250929Read ↗

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APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome.Semantic proximity Read ↗

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Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?Semantic proximity Read ↗

Apo E genotypes and risk of dementia in Down syndrome.Semantic proximity Read ↗

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