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Article

Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down syndrome.

International journal of geriatric psychiatry - 1 Nov 2008

Prasher V P, Sajith S G, Rees S D, Patel A, Tewari S, Schupf N, Zigman W B

Abstract excerpt

OBJECTIVE: Virtually all adults with Down syndrome (DS) have neuropathological manifestations of Dementia in Alzheimer's disease (DAD) but not all develop clinical psychopathology. The effect of allelic variants of Apolipoprotein (APOE) gene in development and progression of DAD and mortality in persons with DS is examined. METHODS: Recruited participants with DS underwent two to 14 sequential assessments over a...

Topics

Alleles
Alzheimer Disease
Apolipoprotein E4
Disease Progression
Down Syndrome
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Testing
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Prospective Studies

Risk Assessment

Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 18464295
DOI: 10.1002/gps.2039
PMCID: PMC2714805

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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