Analysis of the APOE alleles impact in Down's syndrome.

doi:10.1016/s0304-3940(96)13244-4

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Article

Analysis of the APOE alleles impact in Down's syndrome.

Neuroscience letters - 6 Dec 1996

Lambert J C, Pérez-Tur J, Dupire M J, Delacourte A, Frigard B, Chartier-Harlin M C

Abstract excerpt

Down's syndrome (DS) patients develop the characteristic features of Alzheimer's disease (AD) by their fourth decade, some of them exhibiting an AD-type dementia. We studied the apolipoprotein E (APOE) allele distribution in a population of 41 DS patients comprising 19.5% of demented, compared to...

Topics

Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Down Syndrome
Humans
Middle Aged

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