Article
Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia.
Neuroreport - 20 Dec 1994
Royston M C, Mann D, Pickering-Brown S, Owen F, Perry R, Raghavan R, Khin-Nu C, Tyrer S, Day K, Crook R
Abstract excerpt
Although individuals with Down's syndrome nearly always develop the clinical and pathological features of Alzheimer's disease, some clearly do not become demented despite living into their sixth and seventh decades. Genetic variation at the apolipoprotein E locus has recently been shown to be an important determinant of Alzheimer's disease, with the epsilon 4 allele having been shown to be associated with the...
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