Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia.

doi:10.1097/00001756-199412000-00044

Back to search

Article

Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia.

Neuroreport - 20 Dec 1994

Royston M C, Mann D, Pickering-Brown S, Owen F, Perry R, Raghavan R, Khin-Nu C, Tyrer S, Day K, Crook R

Abstract excerpt

Although individuals with Down's syndrome nearly always develop the clinical and pathological features of Alzheimer's disease, some clearly do not become demented despite living into their sixth and seventh decades. Genetic variation at the apolipoprotein E locus has recently been shown to be an...

Topics

Age of Onset
Aged
Alleles
Apolipoproteins E
Dementia
Down Syndrome
Heterozygote
Humans
Longevity
Middle Aged

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.