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Article

A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome.

Biological psychiatry - 15 Mar 1998

Tyrrell J, Cosgrave M, Hawi Z, McPherson J, O'Brien C, McCalvert J, McLaughlin M, Lawlor B, Gill M

Abstract excerpt

BACKGROUND: The apolipoprotein E (ApoE) e4 allele has been associated with an increased risk for Alzheimer's disease, whereas the e2 allele has been shown to be protective. Similar effects in Down's syndrome (DS) have been postulated but not yet demonstrated. METHODS: We obtained DNA from 221 DS individuals and from 162 population controls, and 77 DS children. Older DS subjects were evaluated for dementia and...

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Identifiers

PMID: 9532343
DOI: 10.1016/s0006-3223(97)00481-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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