A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome.

doi:10.1016/s0006-3223(97)00481-2

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Article

A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome.

Biological psychiatry - 15 Mar 1998

Tyrrell J, Cosgrave M, Hawi Z, McPherson J, O'Brien C, McCalvert J, McLaughlin M, Lawlor B, Gill M

Abstract excerpt

BACKGROUND: The apolipoprotein E (ApoE) e4 allele has been associated with an increased risk for Alzheimer's disease, whereas the e2 allele has been shown to be protective. Similar effects in Down's syndrome (DS) have been postulated but not yet demonstrated. METHODS: We obtained DNA from 221 DS...

Topics

Adult
Aged
Alleles
Apolipoprotein E2
Apolipoproteins E
DNA
Dementia
Down Syndrome
Gene Frequency
Genotype
Humans
Middle Aged
Polymerase Chain Reaction

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